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1. Francesco Bagnaia (No change)
– Team: Ducati
– Best GP result: 1st (Portugal, Spain, Italy, Netherlands, Austria, Indonesia, Valencia)
– Best sprint result: 1st (Portugal, America, Italy, Austria)
– Total podiums: 28
– Best qualifying: 1st (America, France, Italy, Germany, Austria, Malaysia, Valencia)
– Championship: 1st (467 points)
2. Jorge Martin (Re-entry)
– Team: Pramac Ducati
– Best GP result: 1st (Germany, San Marino, Japan, Thailand)
– Best sprint result: 1st (France, Germany, San Marino, India, Japan, Indonesia, Thailand, Qatar, Valencia)
– Total podiums: 22
– Best qualifying: 1st (San Marino, Japan, Indonesia, Australia)
– Championship: 2nd (428)
3. Brad Binder (Up 4)
– Team: KTM
– Best GP result: 2nd (Spain, Austria)
– Best sprint result: 1st (Argentina, Spain)
– Total podiums: 12
– Best qualifying: 2nd (Australia)
– Championship: 4th (293 points)
4. Fabio Quartararo (Down 2)
– Team: Yamaha
– Best GP result: 3rd (America, India, Indonesia)
– Best sprint result: 3rd (Netherlands)
– Total podiums: 4
– Best qualifying: 4th (Netherlands, Indonesia)
– Championship: 10th (172 points)
5. Marco Bezzecchi (Up 4)
– Team: VR46 Ducati
– Best GP result: 1st (Argentina, France, India)
– Best sprint result: 1st (Netherlands)
– Total podiums: 13
– Best qualifying: 1st (Netherlands, Britain, India)
– Championship: 3rd (329 points)
6. Aleix Espargaro (Down 1)
– Team: Aprilia
– Best GP result: 1st (Britain, Catalunya)
– Best sprint result: 1st (Catalunya)
– Total podiums: 4
– Best qualifying: 1st (Spain)
– Championship: 6th (206 points)
7. Johann Zarco (New entry)
– Team: Pramac Ducati
– Best GP result: 1st (Australia)
– Best sprint result: 4th (Italy, Britain)
– Total podiums: 6
– Best qualifying: 2nd (Valencia)
– Championship: 5th (225 points)
8. Fabio Di Giannantonio (New entry)
– Team: Gresini Ducati
– Best GP result: 1st (Qatar)
– Best sprint result: 2nd (Qatar)
– Total podiums: 3
– Best qualifying: 2nd (Qatar)
– Championship: 12th (151 points)
9. Alex Marquez (New entry)
– Team: Gresini Ducati
– Best GP result: 2nd (Malaysia)
– Best sprint result: 1st (Britain, Malaysia)
– Total podiums: 4
– Best qualifying: 1st (Argentina)
– Championship: 9th (177 points)
10. Luca Marini (New entry)
– Team: VR46 Ducati
– Best GP result: 2nd (America)
– Best sprint result: 2nd (Indonesia)
– Total podiums: 6
– Best qualifying: 1st (Indonesia, Qatar)
– Championship: 8th (201 points)